Job Description

Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value. The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules.

Incyte is seeking a highly motivated immunologist to join our team as a Sr. Research Investigator. This lab-based role will be focused on developing novel strategies to target the innate immune response for the treatment of autoimmune disease indications. This is a unique opportunity to influence early discovery projects and support pre-clinical translational assays.. Although this is not a requirement, individuals with experience working on Graft-versus-Host Disease (GVHD) and/or lung diseases are encouraged to apply.

Job Summary (Primary function)

The Research Investigator is a lab-based role focused on developing novel strategies to target the innate immune response for the treatment of autoimmune disease indications. This is a unique opportunity to influence early discovery projects and support pre-clinical translational assays. As a Sr. Research Investigator, you will be a key contributor to the Immunology Group’s efforts to better understand the complex the role of the innate immune system in modulating autoimmune disease. To succeed in this position will require a strong background in innate immunology, performing advanced immune-based assays, and a strong desire to translate scientific discoveries into novel therapeutic treatments. The successful candidate will work within a multidisciplinary team.

Essential Functions of the Job (Key responsibilities):

Design, execute, and analyze complex immunological experiments focused on innate immune mechanisms in autoimmune diseases, including:

· Multicolor flow cytometry and/or CyTOF with a focus on innate immune cell populations (e.g., macrophages, neutrophils, mast cells,).

· Develop ex vivo primary cell functional assays using innate immune cells

· Analyze and interpret complex data sets, present findings to internal and external stakeholders, and contribute to scientific publications.

· Contribute to the design and execution of pre-clinical studies to evaluate the efficacy and safety of therapeutic candidates targeting innate immune pathways in autoimmune diseases.

· Collaborate with cross-functional teams, including biologists, chemists, and clinicians, to advance research projects.

· Maintain accurate and detailed records of experimental procedures and results.

· Take on increasing leadership responsibilities, including project leadership and scientific strategy development.

Qualifications (Minimal acceptable level of education, work experience, and competency)

· Ph.D. in Immunology or a related field, with a focus on innate immunity or autoimmunity.

· Minimum of 2-3 years of postdoctoral or industry experience in immunology, preferably with a focus on autoimmune diseases.

· Extensive hands-on experience with advanced immune-based assays, including flow cytometry, CyTOF, multiplex assays, and RNA sequencing, with a focus on innate immune cell analysis.

· Strong understanding of innate immune cell biology, signaling pathways, and their role in autoimmune pathogenesis.

· Experience with cell culture and primary cell isolation techniques, particularly related to innate immune cells

· Experience with preclinical in vivo models of autoimmune disease.

o Individuals with experience in GVHD and/ or lung disease models and/ or myeloid cell research are strongly encouraged to apply.

· Proficiency in data analysis software (e.g., FlowJo, Prism, R).

· Excellent communication, presentation, and interpersonal skills.

· Ability to work independently and as part of a team.

· Strong problem-solving and critical thinking skills.

· Experience with writing scientific publications.

Preferred Skills:

· Knowledge of bioinformatics and data analysis tools

• Experience using software to visualize multi-dimensional flow and CyTOF data (e.g., t-SNE, UMAP, viSNE).

Disclaimer: The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required.

Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.

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